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sparsentan will reduce the extent or outcome of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Keep an eye on. Sparsentan (a CYP2C19 inducer) decreases publicity of CYP2C19 substrates and lessens efficacy related to these substrates.Hou et al (2005) examined the autonomic effects of modafinil in people. They identified that m